发明名称 |
HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODIES TO CD47 |
摘要 |
Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies; and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies. |
申请公布号 |
US2015183874(A1) |
申请公布日期 |
2015.07.02 |
申请号 |
US201514656431 |
申请日期 |
2015.03.12 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
Liu Jie;Weissman Irving L.;Majeti Ravindra |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated chimeric or humanized antibody that specifically binds to human CD47, and comprises at least one CDR sequence as set forth in SEQ ID NO:3-8, SEQ ID NO:20-25; SEQ ID NO:28-33 or SEQ ID NO:61-66. |
地址 |
Palo Alto CA US |