发明名称 |
OLIGONUCLEOTIDE INHIBITOR OF DNA POLYMERASES |
摘要 |
The invention comprises a reversible oligonucleotide inhibitor of nucleic acid polymerases. Methods of designing said inhibitors and using said inhibitors in amplification and detection of nucleic acid, particularly detection of RNA by RT-PCR are also disclosed. |
申请公布号 |
US2015176059(A1) |
申请公布日期 |
2015.06.25 |
申请号 |
US201414562351 |
申请日期 |
2014.12.05 |
申请人 |
Roche Molecular Systems, Inc. |
发明人 |
Fiss Ellen;San Filippo Joseph |
分类号 |
C12Q1/68;C12N9/99;C12N15/113 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. A reversible inhibitor of nucleic acid polymerases comprising a single-stranded DNA oligonucleotide having one or more regions of double-stranded secondary structure, wherein at least one of said regions comprises at least one uracil base. |
地址 |
Pleasanton CA US |