Lipidomimetic compounds and uses thereof

摘要

Disclosed are lipidomimetic compounds of formula I (I) wherein: G represents a group satisfying formula II: HO—CH2—{CH(OH)—CH2-0}m-CH2—{C(=0)-0-CH2})q— formula II each n independently is an integer from 1-30; m is an integer from 1-10; q is 0 or 1. These compounds can be added to the lipid bilayer of thermosensitive liposomes, for the purpose of aiding in the prevention of leakage of the liposomes' contents at 37° C., and retarding clearance from circulation.;

主权项

1. A compound satisfying structural formula I wherein: G represents a group satisfying formula II:
HO—CH2—{CH(OH)—CH2—O}m—CH2—{C(═O)—O—CH2}q—  formula II each n independently is an integer from 1-30; m is an integer from 2-10; q is 0 or 1.