发明名称 |
RECOMBINANT FACTOR VIII HAVING INCREASED STABILITY |
摘要 |
PROBLEM TO BE SOLVED: To provide a recombinant factor VIII that includes one or more mutations that result in enhanced stability of both factor VIII and factor VIIIa.SOLUTION: Methods of making and using the recombinant factor VIII, and pharmaceutical compositions containing the same are disclosed. The present invention further relates to an isolated nucleic acid molecule that encodes the recombinant factor VIII, as well as DNA expression systems and host cells containing the isolated nucleic acid molecule. |
申请公布号 |
JP2015110589(A) |
申请公布日期 |
2015.06.18 |
申请号 |
JP20140264026 |
申请日期 |
2014.12.26 |
申请人 |
UNIV OF ROCHESTER |
发明人 |
PHILIP J FAY;WAKABAYASHI HIRONAO |
分类号 |
C07K14/755;A61K38/36;A61P7/04;C07K14/745;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09 |
主分类号 |
C07K14/755 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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