Inhibition of MyBP-C binding to myosin as a treatment for heart failure

摘要

The present invention provides for methods of treating and slowing the onset of heart failure. The inventors have determined that myosin binding to unphosphorylated Myosin Binding Protein C (MyBP-C) plays a key role in the diminution of cardiac contractile force and frequency in heart failure. The present invention provides peptide inhibitors of the MyBP-C/myosin interaction, thereby increasing both cardiac contractile force and frequency in the failing heart, as well as in patients not yet exhibiting frank heart failure.

主权项

1. A method of treating heart failure comprising:
(a) identifying a patient exhibiting one or more symptoms of heart failure; and (b) administering to said patient a peptide of no more than 50 residues that comprises the MyBP-C binding site for myosin and binds to myosin and comprises the sequence LKKRDXFRRD (SEQ ID NO: 1), where X is A, V or D.