CEFTOLOZANE-TAZOBACTAM PHARMACEUTICAL COMPOSITIONS

摘要

Pharmaceutical compositions can include ceftolozane lyophilized in the absence of tazobactam.

主权项

1. A unit dosage form of a pharmaceutical composition formulated for parenteral administration for the treatment of a complicated intra-abdominal infection or a complicated urinary tract infection, the pharmaceutical composition comprising ceftolozane and tazobactam in a ratio of 1,000 mg ceftolozane active per 500 mg of tazobactam active, the pharmaceutical composition obtained by a process comprising the steps of:
a. lyophilizing a first aqueous solution in the absence of tazobactam, the first aqueous solution comprising ceftolozane, at a pH of 6-7 prior to lyophilization to obtain a first lyophilized ceftolozane composition; b. lyophilizing a second solution comprising tazobactam in the absence of ceftolozane to form a second lyophilized tazobactam composition; and c. blending the first lyophilized ceftolozane composition and the second lyophilized tazobactam composition to obtain the antibacterial composition.