Compositions of humanized notch fusion proteins and methods of treatment

摘要

A fusion protein the sequence of which (a) is identical to the sequence of a portion of the extracellular domain of a human Notch4 receptor followed by (b) a sequence identical to the sequence of an Fc portion of an antibody, wherein the sequence of the portion of the extracellular domain of the human Notch4 receptor is a sequence selected from the group consisting of the sequences of EGF-like repeats 1-13, EGF-like repeats 1-23, EGF-like repeats 9-23, EGF-like repeats 9-29, EGF-like repeats 13-23 and EGF-like repeats 21-29, wherein (b) is located to the carboxy terminal side of (a) and wherein (b) is attached to (a) either directly or by means of a linker sequence.