发明名称 |
PROTEIN BIOMARKER AND USES THEREOF |
摘要 |
The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low. The invention is also directed to methods of performing an ELISA, including sequential steps of contacting a solid surface with a plurality of solutions each comprising in turn a capture antibody, a blocking agent, a sample suspected of containing an analyte, a detection antibody and an enzyme conjugate, in which the solid surface is subjected to a wash process after each sequential step. |
申请公布号 |
US2015147326(A1) |
申请公布日期 |
2015.05.28 |
申请号 |
US201414502769 |
申请日期 |
2014.09.30 |
申请人 |
Daiichi Sankyo Company, Limited ;U3 Pharma GmbH ;Kinki University |
发明人 |
SCHNEIDER Matthias;BLUM Sabine;MENDELL-HARARY Renee Jeanne;FREEMAN Daniel J.;BECKMAN Robert Allen;JIN Xiaoping;YONESAKA Kimio;NAKAGAWA Kazuhiko |
分类号 |
G01N33/574;C07K16/40;A61N5/10;A61K31/517;A61K45/06;C07K16/28;A61K39/395 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Tokyo JP |