MACROCYCLIC FACTOR VIIA INHIBITORS

摘要

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.;

主权项

1. A compound of Formula (I):or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:
W is  wherein the ring moiety is substituted with 0-2F atoms; L is independently selected from: CH(C1-2 alkyl), CF2, CH(CH2F), CH(CHF2), and CH2CH(OH); R1 and R2 are independently selected from: H, C1-2 alkyl and C1-2 alkoxy; R4 and R9 are independently selected from: H, F and Cl; and R8 is independently selected from: —O(CH2)1-4O(C1-4 alkyl), —CON(C1-4 alkyl)2, —SO2(C1-6 alkyl), —SO2(cyclopropyl), —P(═O)(OC1-4 alkyl)2,