MODULATION OF ASYMMETRIC PROLIFERATION

摘要

Provided herein are methods and compositions related to modulation of the rate of asymmetric proliferation of cancer cells. In some embodiments, the methods described herein relate to the treatment of cancer, at least in part, via the modulation of the rate of asymmetric proliferation of cancer cells.

主权项

1. A method of modulating the rate of asymmetric proliferation in a cancer cell, the method comprising:
contacting the cancer cell with a modulator of AKT1 degradation; wherein an increase in AKT1 degradation increases the rate of asymmetric proliferation in the cancer cell; and wherein a decrease in AKT1 degradation decreases the rate of asymmetric proliferation in the cancer cell.