PROTEIN-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF COLORECTAL ADENOCARCINOMA
摘要
<p>Protein-based methods and compositions for the diagnosis of colorectal adenocarcinoma are disclosed. A method for indentifying cell-surface proteins, which are transmembrane proteins or proteins with a signal peptide and which are over-expressed in colorectal cancer (CRC) is disclosed. Biomarkers found with this method, diagnostic methods using them and contrast agents directed to them for use in magnetic resonance imaging (MRI) and/or magnetic photon imaging (MPI) are disclosed.
The methods and biomarkers allow for differentiating progressive (high-risk) CRC (adenocarcinomas) from non-progressive (low-risk) colorectal adenomas.</p>
申请公布号
EP2417457(B1)
申请公布日期
2015.05.13
申请号
EP20100712791
申请日期
2010.03.31
申请人
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORG
发明人
DE WIT, MEIKE;FIJNEMAN, REMONDUS, J., A.;JIMENEZ, CORNELIA, R.;MEIJER, GERRIT, A.