| 摘要 |
FIELD: chemistry.SUBSTANCE: group of inventions relates to methods of opening a ring of a compound, containing a lactone and/or lactam cycle. The methods includes the reaction of the cycle-containing compound, including at least one lactone cycle and/or at least one lactam cycle with at least one amine in the presence of at least one catalyst - monocarboxylic acid in an amount from 0.5 equ to 1.5 equ counted per the quantity of moles of the used cycle-containing compound, with the absence of a catalyst based on a metal salt. The invention also relates to methods of obtaining an amide of ?-amino-?-hydroxy-?-arylalkanoic acid of the general formula(where values of substituents are such as given in the invention formula). The methods of obtaining amides of formula (I) also include a reaction of a cycle-containing compound with at least one amine in the presence of at least one catalyst of the ring opening. One of the methods includes the application of monocarboxylic acid as the catalyst in an amount from 0.5 equ to 1.5 equ counted per the quantity of moles of the used cycle-containing compound, with the absence of the catalyst based on the metal salt. Other method additionally includes the removal of at least one protective group of an amino group or one protective group of a hydroxygroup from an intermediate compound and/or reaction product.EFFECT: opening rings of the compounds, containing the lactone and/or lactam cycle, with higher reaction rate and with the application of a less expensive catalyst.15 cl, 9 dwg, 8 tbl, 190 ex |
