| 主权项 |
1. A method of treating or preventing non-opioid induced gastrointestinal dysfunction in a patient undergoing surgery, comprising the step of:
administering to said patient in need thereof about 0.5 mg/day to about 18 mg/day of an effective amount of at least one 4-aryl-piperidine derivative or a stereoisomer, a prodrug, a pharmaceutically acceptable salt, a hydrate, a solvate, an acid salt hydrate, an N-oxide or an isomorphic crystalline form thereof; in a manner so as to obtain a pharmacokinetic profile wherein the free concentration in the plasma of said patient of said 4-aryl-piperidine derivative or stereoisomer, prodrug, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate, N-oxide or isomorphic crystalline form thereof is sufficient to achieve substantially saturate the μ opioid receptors in the gastrointestinal tract of said patient; wherein said patient is not receiving chronic or periodic exogenous opioids; wherein said gastrointestinal dysfunction is postoperative ileus; and wherein said 4-aryl-piperidine derivative is [[2-[[-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl]-3-phenylpropanoyl]amino]acetic acid. |
