MODIFIED ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODIES AND METHODS OF USE THEREOF
摘要
Provided herein are modified anti-EGFR antibodies and nucleic acid molecules encoding modified anti-EGFR antibodies. Also provided are methods of treatment and uses using modified anti-EGFR antibodies. The modified anti-EGFR antibodies may exhibit a ratio of binding activity for EGFR at pH 6.0-6.5 compared to pH 7.4 that is greater than 1.0.
申请公布号
WO2015038984(A3)
申请公布日期
2015.05.07
申请号
WO2014US55526
申请日期
2014.09.12
申请人
HALOZYME, INC.
发明人
WEI, GE;FROST, GREGORY, IAN;SHEPARD, HAROLD, MICHAEL;THANOS, CHRISTOPHER, D.