Capsule and powder formulations containing lanthanum compounds

摘要

The present invention includes an oral pharmaceutical capsule comprising a shell, lanthanum carbonate or lanthanum carbonate hydrate, and a lubricant such as talc, wherein the shell encapsulates the lanthanum carbonate or its hydrate and the lubricant. Capsule shells comprise, for example, gelatin. The present invention also includes an oral pharmaceutical powder comprising lanthanum carbonate or lanthanum carbonate hydrate and a pharmaceutically acceptable excipient. The oral pharmaceutical capsules and powders of the present invention can be administered to treat a patient at risk of or suffering from hyperphosphatemia, at risk of or suffering from chronic kidney disease (CKD), at risk of or suffering from soft tissue calcification associated with CKD, or at risk of or suffering from secondary hyperparathyroidism.

主权项

1. An oral pharmaceutical powder comprising:
(1) lanthanum carbonate, lanthanum carbonate hydrate, or a combination thereof, wherein the lanthanum carbonate or lanthanum carbonate hydrate comprises elemental lanthanum, and the elemental lanthanum is in an amount of about 26% by weight to about 50% by weight; (2) dextrates in an amount from about 5% to about 50% by weight; (3) one or more flow aids; and (4) one or more lubricants; wherein the weight % of elemental lanthanum is greater than the weight % of the dextrates.