发明名称 |
EX VIVO EXPANSION OF MYOGENIC STEM CELLS BY NOTCH ACTIVATION |
摘要 |
Activating Notch signaling in cultured canine muscle derived cells inhibited myogenic differentiation, and increased the number of myogenic progenitor cells that were similar to quiescent or newly activated satellite cells. Importantly, cells expanded in the presence of Notch activation maintained engraftment potential, indicating the potential for therapeutic benefit. Activation of Notch signaling to inhibit myogenic differentiation in cultured human muscle-derived cells is also contemplated, for maintaining engraftment potential using such human cells in transplantation. |
申请公布号 |
EP2864476(A1) |
申请公布日期 |
2015.04.29 |
申请号 |
EP20130804990 |
申请日期 |
2013.06.14 |
申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER |
发明人 |
PARKER, MAURA, H.;TAPSCOTT, STEPHEN, J. |
分类号 |
C12N5/077;A61K35/34;C07K14/47;C07K19/00;C12Q1/68 |
主分类号 |
C12N5/077 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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