| 发明名称 | Salt form of tyrosine kinase inhibitor | ||
| 摘要 | Provided are acid addition salts of (Z)—N-[2-(diethylamino)ethyl]-2-methyl-7-(1,2 -dihydro-5-fluoro-2-oxo-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indol-3-carboxamide, wherein the salt comprising at least one of a number of salts including L-malate, hydrochloride, phosphate, L-tartrate, benzenesulfonate, sulfate, methanesulfonate, succinate, citrate, fumarate, p-toluenesulfonate, hydrobromate, L-mandelate, lactate, acetate or maleate salt. Also provided is a pharmaceutical composition comprising the salt compounds, and a method of treatment by administering a therapeutically effective amount of the salt compounds as preparation of medicaments. | ||
| 申请公布号 | US9018242(B2) | 申请公布日期 | 2015.04.28 |
| 申请号 | US201314023486 | 申请日期 | 2013.09.11 |
| 申请人 | Jiangsu Simcere Pharmaceutical R&D Co., Ltd | 发明人 | Tang Feng;Jin Qiu;Li Wei;Zhu Tian;Hu Yang;Shao Feng |
| 分类号 | A61K31/4045;C07D209/42 | 主分类号 | A61K31/4045 |
| 代理机构 | Syncoda LLC | 代理人 | Syncoda LLC ;Ma Feng |
| 主权项 | 1. An acid addition salt of (Z)—N-[2-(diethylamino)ethyl]-2-methyl-7-(1,2-dihydro-5-fluoro-2-oxo-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indol-3-carboxamide, wherein the salt comprises at least one of L-malate, citrate, hydrochloride, phosphate, or lactate salt of (Z)—N-[2-(diethylamino)ethyl]-2-methyl-7-(1,2-dihydro-5-fluoro-2-oxo-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indol-3-carboxamide. | ||
| 地址 | Nanjing CN | ||