Crotoxin Administration for Cancer Treatment

摘要

A method for treating cancer using an intra-patient dose escalation procedure to deliver dosages of Crotalus durissus terrificus venom.

主权项

1. A method for treating cancer comprising:
administering to a cancer patient at least one Crotalus durissus terrificus venom dosage of from about 0.04 to about 0.8 mg, the dosage being intravenously administered in an intra-patient dose escalation procedure, the intra-patient dose escalation procedure comprising consecutive administration of: about 0.04 mg/day for a 3-5 day treatment period; about 0.08 mg/day for a 3-5 day treatment period; about 0.12 mg/day for a 3-5 day treatment period; about 0.16 mg/day for a 3-5 day treatment period; about 0.2 mg/day for a 3-5 day treatment period; about 0.24 mg/day for a 3-5 day treatment period; about 0.28 mg/day for a 3-5 day treatment period; about 0.32 mg/day for a 3-5 day treatment period; about 0.36 mg/day for a 3-5 day treatment period; about 0.4 mg/day for a 3-5 day treatment period; about 0.44 mg/day for a 3-5 day treatment period; about 0.48 mg/day for a 3-5 day treatment period; about 0.52 mg/day for a 3-5 day treatment period; about 0.56 mg/day for a 3-5 day treatment period; about 0.6 mg/day for a 3-5 day treatment period; about 0.64 mg/day for a 3-5 day treatment period; about 0.68 mg/day for a 3-5 day treatment period; about 0.72 mg/day for a 3-5 day treatment period; about 0.76 mg/day for a 3-5 day treatment period; and about 0.8 mg/day for a 3-5 day treatment period; and wherein each successive dose escalation is conditioned upon the absence of dose-limiting toxicity from the previous dose.