Beta-Arrestin Effectors And Compositions And Methods Of Use Thereof

摘要

This application describes compounds acting as, for example, β-arrestin effectors and uses thereof, in, for example, the treatment of chronic and acute cardiovascular diseases.

主权项

1. A peptide or peptide mimetic comprising the sequence of
Sar-Zz-Val-Aa-Xx-His-Bb-Yy (SEQ ID NO: 25), wherein: Zz is Arg or Met; Aa is Tyr or D-Cys; Xx is Pro, NMeIle, Ile, cyHex, cyPen, AA01, AA02, or AA03; Bb is Pro, Cys, Pro-NH-iPr, Pro-NH-neopentyl, Pro-NH-Et, or Pro-NH-Me; Yy is any amino acid residue, D-Ala, AA01, AA02, AA03, or null; provided that when Aa is Tyr and Xx is Ile, Bb is not Pro, Pro-NH-iPr, Pro-NH-neopentyl, Pro-NH-Et, or Pro-NH-Me.