用于控管恶心及呕吐之组合物;COMPOSITION FOR THE MANAGEMENT OF NAUSEA AND VOMITING

摘要

本案提供一种医药给药系统，其包含(a)有效量之以下一或多者：杜亚拉明、其类似物、其衍生物、其前药、其代谢物及/或其盐；(b)有效量之以下一或多者：(i)吡哆醇、(ii)其类似物、(iii)其衍生物、(iv)其前药、(v)其代谢物，及(vi)(i)-(v)中任一者之盐；以及(c)有效量之一或多种式(I)化合物其中R为H、PO3 - 或。该系统相对于现行 Diclectin/Diclegis调配物展现改良之药物动力学概况，且适用于例如减轻恶心及呕吐症状，例如适用于减轻妊娠期之恶心及呕吐(NVP)症状。; (b) an effective amount of one or more of (i) Pyridoxine, (ii) an analog thereof, (iii) a derivative thereof, (iv) a prodrug thereof, (v) a metabolite thereof and (vi) a salt of any of (i)-(v); and (c) an effective amount of one or more compounds of formula (I) wherein R is H, PO3 - or. The system exhibits an improved pharmacokinetic profile relative to the current Diclectin/Diclegis formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).