| 摘要 |
A NONAQUEOUS, EXTRUDABLE COMPOSITION INCLUDES AT LEAST ONE THERMOPLASTIC POLYMER IN AN AMOUNT OF MORE THAN 20 WT% OF THE WHOLE COMPOSITION AND TOBACCO. A SMOKELESS TOBACCO PRODUCT IN THE FORM OF A SHEET CAN BE MADE BY EXTRUDING OR HOT MELT SHAPING A NONAQUEOUS COMPOSITION COMPRISING AT LEAST ONE THERMOPLASTIC POLYMER AND TOBACCO, THE SHEET BEING SOLUBLE IN A USER?S MOUTH AND RESULTING IN SUSTAINED RELEASE OF NICOTINE TO THE USER. THE SHEET CAN BE IN A FORM THAT MAY BE PLACED IN THE BUCCAL CAVITY OF, ON THE PALATE OF OR SUBLINGUALLY IN THE USER, AND HAVE AN AVERAGE DISSOLUTION TIME OF 5 TO 50 MINUTES FOR DELIVERING SUPER BIOAVAILABLE NICOTINE TO THE USER. |
