发明名称 |
METHOD FOR PREVENTING ANTHRACYCLINE CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER |
摘要 |
FIELD: medicine.SUBSTANCE: in the patients diagnosed with breast cancer and recommended to have a chemotherapeutic course, the heart rate is measured one week before the treatment according to electrocardiography after a 5-minute rest. If the measured heart rate is 70 beats per minute or more, ivabradine is prescribed in a daily dose of 10 mg. Electrocardiography is repeated after a 5-minute rest 4 weeks later. If the measured heart rate is 70 beats per minute or more, the dose is titration is made to 15 mg a day. If the measured follow-up heart rate is less than 70 beats per minute, the daily dose is kept at 10 mg. If the initial heart rate is less than 70 beats per minute, trimetasidine is prescribed in a daily dose of 70 mg for the whole period of treatment independent from the further heart rate measurement. All the patients take the preparation throughout the duration of 6 months.EFFECT: method enables reducing the cardiotoxic action of the anthracycline chemopreparations in the patients with breast cancer.3 ex, 4 dwg |
申请公布号 |
RU2546399(C1) |
申请公布日期 |
2015.04.10 |
申请号 |
RU20140117355 |
申请日期 |
2014.04.30 |
申请人 |
GOSUDARSTVENNOE BJUDZHETNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "MOSKOVSKIJ GOSUDARSTVENNYJ MEDIKO-STOMATOLOGICHESKIJ UNIVERSITET IMENI A.I. EVDOKIMOVA" MINISTERSTVA ZDRAVOOKHRANENIJA ROSSIJSKOJ FEDERATSII (MGMSU IMENI A.I. EVDOKIMOVA MINZDRAVA ROSSII) |
发明人 |
VASJUK JURIJ ALEKSANDROVICH;SHKOL'NIK EVGENIJ LEONIDOVICH;NESVETOV VALERIJ VALER'EVICH;SHKOL'NIK LEONID DONOVICH;VARLAN GENNADIJ VALENTINOVICH;PIL'SHCHIKOV ANDREJ VALER'EVICH |
分类号 |
A61B5/0402 |
主分类号 |
A61B5/0402 |
代理机构 |
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代理人 |
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地址 |
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