| 发明名称 |
FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1 |
| 摘要 |
The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them. |
| 申请公布号 |
WO2015049535(A1) |
申请公布日期 |
2015.04.09 |
| 申请号 |
WO2014GB52992 |
申请日期 |
2014.10.03 |
| 申请人 |
CANCER RESEARCH TECHNOLOGY LIMITED |
发明人 |
JONES, KEITH;RYE, CARL;CHESSUM, NICOLA;CHEESEMAN, MATTHEW;PASQUA, ADELE ELISA;PIKE, KURT GORDON;FAULDER, PAUL FRANK |
| 分类号 |
C07D405/14;A61K31/357;A61K31/404;A61K31/428;A61K31/436;A61P35/00;C07D319/08;C07D405/12;C07D407/12;C07D409/12;C07D417/12;C07D417/14;C07D471/04;C07D487/08;C07D491/056 |
主分类号 |
C07D405/14 |
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