发明名称 |
Formulation of diclofenac |
摘要 |
The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac, medicaments produced using diclofenac in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of diclofenac administered by way of said medicaments. |
申请公布号 |
US8999387(B2) |
申请公布日期 |
2015.04.07 |
申请号 |
US201414167652 |
申请日期 |
2014.01.29 |
申请人 |
iCeutica Pty Ltd. |
发明人 |
Dodd Aaron;Meiser Felix;Norret Marck;Russell Adrian;Bosch H William |
分类号 |
A61K9/14;A61K31/196;A61K9/48;A61K9/51;A61K9/00 |
主分类号 |
A61K9/14 |
代理机构 |
Fish & Richardson P.C. |
代理人 |
Fish & Richardson P.C. |
主权项 |
1. A method for treating pain comprising administering a solid oral unit dose of a pharmaceutical composition containing 18 mg of diclofenac acid, wherein the diclofenac acid has a median particle size, on a volume average basis, of less than 1000 nm and greater than 25 nm, wherein the unit dose, when tested in vitro by USP Apparatus I (Basket) method of U.S. Pharmacopoeia at 100 rpm, at 37° C. in 900 ml of 0.05% sodium lauryl sulfate in citric acid solution buffered to pH 5.75, has a dissolution rate of diclofenac acid such that at least 94%, by weight, is released by 75 minutes. |
地址 |
Philadelphia PA US |