Precursors of glutamate derivatives

摘要

This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.

主权项

1. A compound of the formula I wherein R1 is triphenylmethyl, A is selected from the group consisting of:
a) Monocyclic aryl,b) Bicyclic aryl,c) Biaryl,d) Monocyclic heteroaryl, ande) Bicyclic heteroaryl optionally, A is bearing one or more substituents selected from the group consisting of:
a) Halogen,b) Nitro,c) Alkyl,d) Trifluoromethyl, ande) Z, wherein Z is where R1 is triphenylmethyl, and # indicates the position of the bond to A, or a single isomer, tautomer, diastereomer, enantiomer or stereoisomer thereof, or mixtures thereof, or a suitable salt thereof.