| 主权项 |
1. A compound of formula V, wherein
Q is selected from the. group consisting of G is selected from the group consisting of alkyl, substituted alkyl, substituted or unsubstituted aryl, heterocyclo, W is O or NR15;X is O or H,H;Y is selected from the group consisting of O; H2OR16; OR17,OR17; NOR18; H,NOR19; H,NR20R21; H,H; or CHR22; OR17OR17 can be a cyclic ketal;Z1 and Z2 are selected from the group consisting of CH2, O, NR23, S, or SO2, wherein only one of Z and Z2 is a heteroatom;B1 and B2 are selected from the group consisting of OR24, or OCOR25, or O2CNR26R27; when B1 is H and Y is OH, H they can form a six-membered ring ketal or acetal;D is selected from the group consisting of NR28R29, NR30COR31 or saturated heterocycle;R1, R2, R3, R4, R5, R6, R7, R13, R14, R18, R19, R20, R21, R22, R26, and R27 are selected from the group H, alkyl, substituted alkyl, or aryl and when R1 and R2 are alkyl can be joined to form a cycloalkyl; R3 and R4 are alkyl can be joined to form a cycloalkyl;R9, R10, R16, R17, R24, R25, and R31 are selected from the group H, alkyl, or substituted alkyl;R8, R11, R12, R28, R30, R32, R33, and R30 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or heterocyclo;R15, R23 and R29 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, heterocyclo, R32C═O, R33SO2, hydroxy, O-alkyl or O-substituted alkyl, the pharmaceutically acceptable salts thereof and any hydrates, solvates or geometric, optical and stereoisomers thereof, with the proviso that compounds whereinW and X are both O; andR1, R2, R7, are H; andR3, R4, R6, are methyl; andR8, is H or methyl; andZ1, and Z2, are CH2; andG is 1-methyl-2-(substituted-4-thiazolyl)ethenyl; andQ is as defined above are excluded,
wherein,“alkyl” means a straight or branched chain unsubstituted hydrocarbon group of 1 to 7 carbon atoms;“substituted alkyl” means an alkyl group substituted with one to four substituents selected from trifluoromethyl, trifluoromethoxy, hydroxy, alkoxy, cycloalkoxy, heterocyclooxy, oxo, alkanoyl, aryloxy, alkanoyloxy, amino, alkylamino, arylamino, aralkylamino, cycloalkylamino, heterocycloamino, disubstituted amines in which the 2 amino substituents are selected from alkyl, aryl or aralkyl, alkanoylamino, aroylamino, aralkanoylamino, substituted alkanoylamino, substituted arylamino, substituted aralkanoylamino, thiol, alkylthio, arylthio, aralkylthio, cycloalkylthio, heterocyclothio, alkylthiono, arylthiono, aralkylthiono, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, —SO2NH2, substituted sulfonamido, nitro, cyano, carboxy, —CONH2, —CONH alkyl, CONHaryl, CONHaralkyl, alkoxycarbonyl, aryl, substituted aryl, guanidine, indolyl, imidazolyl, furyl, thienyl, thiazolyl, pyrrolidyl, pyridyl, and pyrimidyl; wherein when the alkyl substituent is further substituted it will be with halogen, alkyl, alkoxy, aryl or aralkyl;“cycloalkyl” means an optionally-substituted, saturated cyclic hydrocarbon ring systems containing 1 to 3 rings and 3 to 7 carbons per ring which may be further fused with an unsaturated C3-C7 carbocyclic ring, wherein when substituted, the substituents will include one or more substituents as recited above as alkyl substituents;“aryl” means a monocyclic or bicyclic aromatic hydrocarbon groups having 6 to 12 carbon atoms in the ring portion;“substituted aryl” means an aryl group substituted by one to four substituents selected from alkyl, substituted alkyl, halo, trifluoromethoxy, trifluoromethyl, hydroxy, alkoxy, cycloalkyloxy, heterocyclooxy, alkanoyl, alkanoyloxy, amino, alkylamino, aralkylamino, cycloalkylamino, heterocycloamino, dialkylamino, alkanoylamino, thiol, alkylthio, cycloalkylthio, heterocyclothio, ureido, nitro, cyano, carboxy, carboxyalkyl, carbamyl, alkoxycarbonyl, alkylthiono, arylthiono, alkysulfonyl, sulfonamido, and aryloxy, wherein when the aryl substitute is further substituted, it will be with halo, hydroxy, alkyl, alkoxy, aryl, substituted alkyl or aralkyl;“heterocyclo” means an optionally substituted, fully saturated or unsaturated, aromatic or nonaromatic cyclic group which is a 4 to 7 membered monocyclic, 7 to 11 membered bicyclic, or 10 to 15 membered tricyclic ring system, which has at least one heteroatom in at least one carbon atom-containing ring, each ring of the heterocyclic group containing a heteroatom may have 1, 2 or 3 heteroatoms, wherein the term “heteroatoms” shall include oxygen, sulfur and nitrogen; and wherein when substituted, the substituted heterocyclo group will include one or more substituents as recited above as alkyl substituents. |
