发明名称 |
COMPOSITIONS AND METHODS FOR CANCER IMMUNOTHERAPY |
摘要 |
<p>The present invention provides a combination therapy which relies on a small molecule immune stimulator—cyclic-di-nucleotide (CDN)—that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes) formulated with allogeneic human tumor cell lines engineered to secrete high amounts of GM-CSF. This combination therapy can provide an ideal synergy of multiple tumor associated antigens, DC recruitment and proliferation, coupled with a potent DC activation stimulus.</p> |
申请公布号 |
KR20150022996(A) |
申请公布日期 |
2015.03.04 |
申请号 |
KR20157000522 |
申请日期 |
2013.06.07 |
申请人 |
ADURO BIOTECH;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
DUBENSKY THOMAS W.;LEONG MEREDITH LAI LING;PARDOLL DREW M.;KIM YOUNG JUN |
分类号 |
A61K48/00;A61K9/127;A61K39/39 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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