Compositions and methods comprising binding proteins for adalimumab

摘要

Compositions and methods comprising proteins that bind specifically to adalimumab are disclosed herein. Adalimumab is a monoclonal antibody specific for the cytokine TNF-α and was developed to treat TNF-α mediated inflammatory diseases. In one aspect of the instant invention, the binding proteins are antibodies directed toward adalimumab. These antibodies, including binding fragments thereof, can be used in a clinical setting as well as for research and development. For example, these anti-adalimumab antibodies can be employed to neutralize adalimumab.

主权项

1. An isolated anti-adalimumab monoclonal antibody, or an antigen binding portion thereof, wherein said antibody is antibody 5A1-2A8, produced by a hybridoma having ATCC accession no. PTA-8513, or an antigen-binding portion thereof.