Antigens and Vaccines Directed Against Human Enteroviruses

摘要

The instant invention provides materials and methods for producing immunologically active antigens derived from members of the Picornaviridae virus family. The picornavirus antigens of the invention may be in a form for use as a vaccine administered to a subject in a therapeutic treatment or for the prevention of a picornavirus infection. The picornavirus antigens of the invention may be in the form of an immunogenic composition for use in vaccines which are administered for the prevention of an Enterovirus infection. The instant invention further encompasses immunogenic compositions comprising Human enterovirus A, Human enterovirus B, Human enterovirus C, Human enterovirus D antigens and their use in vaccines for the prevention of an Enterovirus infection.

主权项

1. A vaccine comprising a virus-like particle, the virus-like particle comprising an Enterovirus polypeptide, the Enterovirus polypeptide comprising any combination of a P1 polypeptide, a VP0 polypeptide, a VP1 polypeptide, a VP2 polypeptide, a VP3 polypeptide, a VP4 polypeptide, or immunologically active fragments thereof, wherein the vaccine elicits a protective and/or neutralizing immune response directed against a human Enterovirus.