发明名称 |
VACCINATION WITH RECOMBINANT MYCOBACTERIUM TUBERCULOSIS PKND ATTENUATES BACTERIAL DISSEMINATION TO THE BRAIN |
摘要 |
Vaccines comprising Mycobacterium tuberculosis (M. tuberculosis) PknD sensor polypeptides, compositions, kits, and methods of use for treating central nervous system tuberculosis are disclosed. More specifically, the disclosure provides a method for treating or preventing central nervous system (CNS) tuberculosis (TB) in a subject, the method comprises administering to the subject a therapeutically effective amount of a vaccine comprising an M tuberculosis PknD sensor polypeptide, or an immunogenic fragment for inhibiting or preventing M tuberculosis bacterial invasion of brain microvascular endothelia. |
申请公布号 |
WO2014200855(A3) |
申请公布日期 |
2015.02.05 |
申请号 |
WO2014US41327 |
申请日期 |
2014.06.06 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
JAIN, SANJAY, K.;SKERRY, CIARAN;BE, NICHOLAS, A. |
分类号 |
A61K38/00;A61K38/04;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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