P2X3, receptor antagonists for treatment of pain

摘要

The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.

主权项

1. A compound represented by structural formula II:or pharmaceutically acceptable salts and individual enantiomers and diastereomers thereof wherein:
A is CH or N; Rb is C1-6 alkyl, or halogen; R2 represents H, C1-6 alkyl, CF3, OH; R3 represents (CHR2)nC5-10 heterocycle,said heterocyclyl substituted with 1 to 3 groups of Ra , wherein R2 in (CHR2)nC5-10 heterocycle is C1-6 alkyl which is methyl and n in (CHR2)nC5-10 heterocycle is 1 ; R6 represents C1-6 alkyl, (CHR2)nC6-10 aryl, (CHR2)nC5-10 heterocyclyl, said alkyl, aryl and heterocyclyl optionally substituted with 1 to 3 groups of Ra ; Ra represents C1-6 alkyl, halogen, OR2, (CH2)nCF3 , —O—, C3-6 cycloalkyl, C(O)N(R2)2, C(O)R2, CN, N(R2)2, C(O)OR2, SO2R2,(CHR2)nC5-10 heterocyclyl, or (CHR2)nC6-10 aryl, said heterocyclyl and aryl optionally substituted with 1 to 3 groups of C1-6 alkyl, halogen, hydroxyl, (CH2)nCF3,or CN; and n represents 0 to 4.