| 摘要 |
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are substantially pure 2', 5', 2', 5' and 2', 5 ',3 ',5' CDNs, and prefereably Rp,Rp stereosiomers thereof. |
| 申请人 |
ADURO BIOTECH, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
DUBENSKY, THOMAS, W., JR.;KANNE, DAVID, B.;LEONG, MEREDITH, LAI LING;GLICKMAN, LAURA, HIX;VANCE, RUSSELL, E.;LEMMENS, EDWARD, EMILE |
