COMPOSITIONS AND METHODS FOR TREATING HIV-1-ASSOCIATED CHRONIC IMMUNE ACTIVATION

摘要

The invention provides compositions and methods for treating HIV-associated chronic immune activation in HIV-positive patients, or for preventing the same in patients at risk of being infected by HIV. The compositions of the invention include antagomirs that antagonize the function of certain HIV-derived viral microRNA (vmiR), which vmiR may lead to chronic immune activation in HIV-positive patients by non-canonical activation of certain pro-inflammatory cytokine pathways.