Hydrophobic polysaccharides with silyl ether linkages having enhanced degradation and medical articles made therefrom

摘要

Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a silyl ether chemistry that facilitates degradation of the polymer. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.

主权项

1. An implantable or injectable medical article, the article comprising a bioactive agent releasable from the article and a biodegradable polymeric matrix or composition comprising a hydrophobic α(1→4)glucopyranose polymer, the polymer comprising:
(i) a poly-α(1→4)glucopyranose portion comprising glucopyranose monomeric units; and (ii) a pendent group from the poly-α(1→4)glucopyranose portion comprising one or more hydrocarbon group(s) linked to a monomeric unit of the poly-α(1→4)glucopyranose portion via a linker segment comprising a silyl ether group.