主权项 |
1. A composition comprising a morpholino compound in combination with a cetylpyridinium salt, the morpholino compound having the general formula (I)wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxyl group except in the alpha-position, or pharmaceutically acceptable salts thereof, for use in the treatment or prevention of an infection or condition in a patient caused by a microbe selected from the group consisting of Staphylococcus spp, Actinobacillus spp, Campylobacter spp, Fusobacterium spp, Eikenella spp, Cornybacterium spp, Finegoldia spp, Anaerococcus spp, Serratia spp, Escherichia spp, Enterococcus spp, Candida spp, Prevotella spp, Cornybacterium spp, Peptoniphilus spp, Finegoldia spp, Peptostreptococcus spp, Actinomyces spp, Pseudomonas spp and Porphyromonas spp and combinations thereof, wherein the infection is in a wound of the skin or mucosa of a patient, or the condition is periodontitis. |