Producing a sustained-release preparation

摘要

This invention provides a production method for a solid sustained-release preparation, characterized in that a sustained-release preparation (a sustained-release preparation suspension) is freeze-dried in a freeze-drying container whose inner face is partially or totally coated with an ice layer or water-repelling base material.

主权项

1. A method for preventing scattering of a sustained-release microcapsule preparation in the production of a solid sustained-release microcapsule preparation, which comprises
1) preparing the sustained-release microcapsule preparation by an aqueous drying method, 2) dispensing water in a freeze-drying container and freezing it to form an ice layer, 3) dispensing a water suspension of the sustained-release microcapsule preparation in the freeze-drying container to form a frozen layer, and 4) freeze-drying the water suspension in the freeze-drying container comprising an inner face that is partially or wholly coated with an ice layer, so as to prevent scattering of the sustained-release microcapsule preparation, wherein said sustained-release microcapsule preparation contains a drug and a lactic acid-glycolic acid polymer, and wherein the water suspension comprises mannitol.