| 摘要 |
<p>The present invention relates to a pharmaceutical composition and a health supplement for preventing or treating thrombosis which include Arctiumlappa extract as an active ingredient and, more specifically, to a pharmaceutical composition and a health supplement for preventing or treating thrombosis which include ethanol extract of the Arctiumlappa extract as an active ingredient. The Arctiumlappa extract as the active ingredient of the pharmaceutical composition and health supplement for preventing or treating thrombosis of the present invention is prepared by successively fractioning using hexane, ethyl acetate, and butanol after preparing an extract by extracting the Arcriumlappa using ethanol as being proved through an embodiment of the specification. The ethyl acetate fraction which has antithrombotic activities by suppressing thrombin direction inhibition, prothrombin inhibition and blood coagulation factor inhibition effects can efficiently suppress thrombosis and can be used for preventing and treating thrombosis such as ischemic stroke and cerebral hemorrhage through improvement of blood flow. Especially, the Arctiumlappa extract of the present invention does not show oral acute toxic, has enhanced thermal stability, does not show loss of thrombosis under pH2 acid condition and inside plasma in order to be prepared in forms which can be taken at any time by being processed into various forms such as extract, powder, pill, tablet, and the likes so that the Arctiumlappa extract is useful invention in food and drug industries.</p> |
