Compositions and methods for inhibition of retroviruses

摘要

Described herein are methods and compositions for the inhibition of retroviral integration and replication. The methods and compositions inhibit the activity of one or more components of the SET complex or base excision repair enzymes and induce autointegration of retroviral double-stranded nucleic acid.

主权项

1. A method of decreasing retroviral nucleic acid integration into a host cell genome, said method comprising contacting a cell infected with a retrovirus with an inhibitor of one or more components of the SET complex, wherein said inhibitor decreases retroviral nucleic acid integration and wherein said inhibitor is a nucleic acid inhibitor comprising a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, and SEQ ID NO:9.