Integration of very short electric pulses for minimally to noninvasive electroporation

摘要

The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) or supra-poration to cause cell death in treated tumors. In embodiments, the methods comprise the integration of ultra-short electric pulses, both temporally and spatially, to achieve the desired modality of cell death.

主权项

1. A method of treating a subject suffering from an aberrant cell growth, said method comprising:
implanting an electrode into or adjacent the aberrant growth region within the body of a subject, and causing a train of electrical pulses to be emitted from the electrode into the aberrant growth region, wherein each individual pulse in the pulse train is incapable of IRE alone but together as the pulse train capable of causing predominately non-thermal killing of aberrantly growing cells by IRE.