Platelet preservation package comprising a short to ultra-short acting antiplatelet agent and anticoagulant

摘要

The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.

主权项

1. A platelet preservation package, comprising: a platelet preservation composition comprising:
a short-to-ultrashort acting antiplatelet agent, wherein said antiplatelet agent is a GPIIb/IIIa inhibitor; a short-to-ultrashort acting anticoagulant, wherein said anticoagulant is a compound that reversibly inhibits factor Xa, or factor IIa, or both; and a bag for storing the platelet preservation composition, wherein said antiplatelet agent and said anticoagulant are stored in said bag and wherein said composition is capable of extending the shelf-life of platelets when mixed with said platelets in said bag.