| 发明名称 |
Method for Inducing a TRIF-Bias |
| 摘要 |
Compositions comprising a selected aminoalkyl glusoaminide 4-phosphate (AGP) CRX-547 to induce a TRIF-biased response in a human system, which results in reduced levels of MyD88-dependent cytokines relative to the MyD88-dependent cytokines induced by its diastereomer AGP CRX-527. |
| 申请公布号 |
US2015004180(A1) |
申请公布日期 |
2015.01.01 |
| 申请号 |
US201314139074 |
申请日期 |
2013.12.23 |
| 申请人 |
GLAXOSMITHKLINE BIOLOGICALS S.A. |
发明人 |
BOWEN WILLIAM S.;EVANS Jay T.;HUTTON MELINDA M.;JOHNSON DAVID A.;MINNS LAURIE A. |
| 分类号 |
A61K31/665 |
主分类号 |
A61K31/665 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A lipid A mimetic composition with an improved therapeutic index comprising:
a first and a second aminoalkyl glucosaminide phosphate (AGP) wherein the first AGP is not CRX 547 and wherein the second AGP is CRX 547 and wherein the therapeutic index of the composition is improved by substantially maintaining or increasing a TRIF-dependent cytokine reponse and by lowering a MyD88-dependent cytokine response relative to the TRIF-dependent cytokine reponse and MyD88-dependent cytokine response of the composition in the absence of CRX 547. |
| 地址 |
Rixensart BE |
