Targeting Tumor Neovasculature with Modified Chimeric Antigen Receptors

摘要

A T cell transduced with a chimeric antigen receptor can be administered to a host to kill cancer cells. The chimeric antigen receptor can include a targeting moiety with a strong binding affinity to αvβ3 integrin, including but not limited to an echistatin polypeptide. The targeting moiety can also be modified to have a reduced binding affinity to α5β1 integrin.

主权项

1. A compound for killing cancer cells comprising:
a T-cell engrafted with a chimeric antigen receptor (CAR), wherein the CAR comprises a targeting moiety that has a strong binding affinity to αvβ3 integrin.