发明名称 |
METHOD OF MAKING ISOIDIDE |
摘要 |
Disclosed is a process for the preparation of isoidide from isosorbide. An aqueous solution of isosorbide is subjected to epimerization in the presence of hydrogen under the influence of a catalyst comprising ruthenium on a support, preferably a carbon support. The process of the invention can be conducted using a relatively low hydrogen pressure, and leads to a desired distribution of epimers, favoring isoidide over isomannide and isosorbide. |
申请公布号 |
US2014371472(A1) |
申请公布日期 |
2014.12.18 |
申请号 |
US201314375230 |
申请日期 |
2013.02.19 |
申请人 |
Stichting Dienst Landbouwkundig Onderzoek |
发明人 |
Hagberg Erik;Martin Kevin;Le Notre Jerome;van Es Daniel Stephan;van Haveren Jacobus;van EE Jan |
分类号 |
C07D493/04;B01J23/755;B01J23/42;B01J23/52;B01J23/46;B01J23/44 |
主分类号 |
C07D493/04 |
代理机构 |
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代理人 |
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主权项 |
1. A process for the preparation of a thermodynamic equilibrium concentration of isoidide from isosorbide, comprising subjecting an aqueous solution of isosorbide to epimerization in the presence of hydrogen under the influence of a catalyst comprising ruthenium on a support, at a starting pH of above 7, for a sufficient time and under other conditions suitable for obtaining a thermodynamic equilibrium condition. |
地址 |
PB Wageningen NL |