发明名称 |
NEURAL MODULATION DEVICES AND METHODS |
摘要 |
A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency. |
申请公布号 |
US2014350632(A1) |
申请公布日期 |
2014.11.27 |
申请号 |
US201414453183 |
申请日期 |
2014.08.06 |
申请人 |
EnteroMedics Inc. |
发明人 |
Tweden Katherine S.;Waataja Jonathan J.;Donders Adrianus P.;Knudson Mark B. |
分类号 |
A61N1/36 |
主分类号 |
A61N1/36 |
代理机构 |
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代理人 |
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主权项 |
1. A system for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising:
at least one electrode adapted to be placed at a vagus nerve; an implantable neuroregulator configured to apply a therapy cycle to the electrode, wherein each therapy cycle comprises a) a burst of electrical signal having a first selected frequency of at least 1000 Hz, wherein the high frequency burst of electrical signals comprises one or more pulses that have a pulse width of about 0.01 milliseconds to about 0.09 milliseconds, and a current of about 0.1 to 20 mAmps; b) more than one burst of a second waveform, each burst having a second selected frequency of at least 40 Hz and less than 150 Hz, wherein each of the bursts of low frequency electrical signals comprises one or more pulses that have a pulse width of about 0.05 microseconds to about 0.5 microseconds, a current of about 0.1 to 20 mAmps and a delay period between each burst; wherein the first and second waveforms are delivered during the same therapy cycle and at least partially downregulate activity on the nerve; c) an on period of at least 2 minutes d) an off period, wherein the off period is selected to allow at least partial recovery of nerve activity; and e) a total charge of about 1000 microcoulombs or less per therapy cycle. |
地址 |
St. Paul MN US |