Tyrosine, Serine and Threonine Phosphorylation Sites

摘要

The invention discloses 155 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.

主权项

1. An antibody or antigen-binding fragment thereof, wherein the antibody specifically binds to an amino acid sequence comprising a phosphorylation site identified in Table 1 when the tyrosine, serine or threonine in Column D is phosphorylated, and wherein the antibody does not bind to said amino acid sequence when the tyrosine, serine or threonine is not phosphorylated.