| 发明名称 |
PROCESS FOR THE PURIFICATION OF POLYAMINOCARBOXYLATES |
| 摘要 |
The present invention relates to an improved process for the purification of polyaminocarboxylates such as DOTA, DTPA, DO3A-butrol, BOPTA. |
| 申请公布号 |
US2014323719(A1) |
申请公布日期 |
2014.10.30 |
| 申请号 |
US201214360059 |
申请日期 |
2012.11.26 |
| 申请人 |
Biophore India Pharmaceuticals Pvt. Ltd. |
发明人 |
Rangisetty Jagadeesh Babu;Pullaguria Manik Reddy;Bhudeti Rajesh |
| 分类号 |
C07C227/42;C07C229/26;C07D257/02 |
主分类号 |
C07C227/42 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for the purification of polyaminocarboxylates like DOTA, DTPA, DO3A-butrol, BOPTA which comprises:
a) treating an aqueous solution polyaminocarboxylate with an inorganic acid, wherein the pH of the solution is below 0.75 b) recrystallizing the precipitated polyaminocarboxylate acid salt in water or water solvent mixtures c) treating the aqueous solution of polyaminocarboxylate acid salt with a resin or a basic solution to maintain pH at 1.5 to 3.0 d) isolating the pure polyaminocarboxylate chelate. |
| 地址 |
Hyderabad, Andhra Pradesh IN |
