Methods for increasing genetic gain in a breeding population

摘要

Methods for method for increasing genetic gain in a breeding process are provided. Also provided are methods for choosing breeding pairs predicted to produce progeny having desired phenotypes, methods for increasing the likelihood of producing progeny individual having desired phenotypes, methods for generating progeny individual having desired genotypes and/or phenotypes, progeny produced thereby, and cells, seeds, parts, and tissues cultures thereof.

主权项

1. A method for increasing genetic gain in a breeding population, the method comprising:
(a) providing effects with respect to a trait of interest of a plurality of genome-wide markers in a breeding population comprising a plurality of potential breeding partners; (b) selecting from the breeding population a first breeding pair comprising a first breeding partner and a second breeding partner, wherein crossing the first breeding partner and the second breeding partner would produce a segregating progeny population; (c) inferring or determining haplotypes with respect to the plurality of genome-wide markers for the first breeding partner and the second breeding partner; (d) simulating a cross between the first breeding partner and the second breeding partner to produce a progeny generation, each member of the progeny generation comprising a simulated genotype; (e) calculating a genetic potential value of the progeny generation, wherein the genetic potential value of the progeny generation is the mean of the genomic breeding values of the simulated genotypes of the member of the progeny generation; (f) repeating steps (b)-(e) one or more times, wherein in each iteration of step (b), the selecting comprises selecting a different first breeding partner, a different second breeding partner, or both from the breeding population; (g) ranking each simulated cross of step (d) based on the genetic potential values calculated in step (e); and (h) selecting one or more breeding pairs based on the ranking of step (g),wherein crossing the breeding pair selected in step (g) is predicted to generate progeny with increased genetic gain, and further wherein the inferring step, the simulating step, or both are performed by a suitably-programmed computer.