Method for obtaining optically pure amino acids

摘要

This invention relates to a method for obtaining optically pure amino acids, including optical resolution and optical conversion. This method significantly shortens the time taken for optical transformation, and enables the repeated use of an organic solution containing a enantioselective receptor, to thereby obtain optically pure amino acids in a simple and remarkably efficient manner, and to enable the very economical mass production of optically pure amino acids.

主权项

1. A method of obtaining optically pure amino acids using a basic aqueous solution containing an amino acid to be optically resolved or optically converted; an organic solution containing a stereo-selective receptor that enantioselectively reacts with D- or L-amino acid to form an imine; and an acidic aqueous solution, the method comprising:
a first step of mixing the basic aqueous solution and the organic solution with stirring, and separating a basic aqueous solution layer and an organic solution layer; a second step of mixing the organic solution separated in the first step with the acidic aqueous solution with stirring, and separating an acidic aqueous solution layer and the organic solution layer; and a third step of recovering D- or L-amino acid from the acidic aqueous solution separated in the second step; wherein the stereo-selective receptor is a compound represented by Chemical Formula 1 below: wherein, R1 is hydrogen; C1˜C10 alkyl substituted or unsubstituted with one or more substituents selected from the group consisting of halogen and OH; C4˜C10 cycloalkyl substituted or unsubstituted with one or more substituents selected from the group consisting of halogen and OH; or C6˜C12 aryl substituted or unsubstituted with one or more substituents selected from the group consisting of halogen and OH; R2 is —NHCX′R3, wherein X′ is oxygen or sulfur; R3 is —NR6R7; R6 and R7 are each independently hydrogen; C1˜C10 alkyl substituted or unsubstituted with halogen; C6˜C12 aryl substituted or unsubstituted with halogen; or C1˜C5 alkyl and C1˜C5 perfluoroalkyl; and wherein, the organic solution further comprises a phase transfer catalyst (PTC).