GOLD-IN-SILICON NANOASSEMBLY FOR THERMAL THERAPY AND METHODS OF USE

摘要

The present invention provides methods and compositions for the nanotechnology-based therapy of one or more mammalian diseases. Disclosed are gold-in-porous silicon nanoassemblies that are effective in the targeted and localized treatment of one or more human hyperproliferative disorders, including, for example, cancer of the breast. Methods of systemic administration of these nanoassembly vectors are disclosed that facilitate direct thermal ablative therapy of selected tissues using a localized application of near-infrared energy to the target site, wherein the gold-in-porous silicon nanoparticles release heat to destroy the surrounding cancerous tissue.

主权项

1. A composition comprising a first-stage particle that comprises porous or nanoporous silicon, and which has (i) a body, (ii) at least one surface; and (iii) at least one reservoir inside the body, such that the reservoir is adapted and configured to contain at least one second-stage particle that comprises solid gold or hollow gold.