| 发明名称 |
BISPHOSPHONATE COMPOSITIONS AND METHODS FOR TREATING AND/OR REDUCING CARDIAC DYSFUNCTION |
| 摘要 |
The present invention provides for methods and compositions for treating, reducing and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, prodrug thereof, functional analogue or a pharmaceutically effective salt thereof in an amount sufficient to increase activity of at least one kinase in heart tissue of the subject. |
| 申请公布号 |
US2014296166(A1) |
申请公布日期 |
2014.10.02 |
| 申请号 |
US201214358468 |
申请日期 |
2012.11.14 |
| 申请人 |
DUKE UNIVERSITY |
发明人 |
Lyles Kenneth W.;Colon-Emeric Cathleen S.;O'Connor Christopher M.;Abraham Dennis;Nilson Kent;Rockman Howard;Russell Graham |
| 分类号 |
A61K31/675;A61K45/06;A61K31/663 |
主分类号 |
A61K31/675 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for preventing or reducing the effects of heart failure in a subject, the method comprising: administering to the subject a dosage of a bisphosphonate, prodrug thereof, functional analogue, or a pharmaceutically acceptable salt thereof in an amount sufficient to increase activity of at least one kinase having biologically activity in heart tissue of the subject. |
| 地址 |
Durham NC US |
